Roche Cobas Integra 400 +

  • Troughput of Up to 400 tests/hr with ISE
  • Sample types: Serum, plasma, urine, CSF, hemolysate and whole blood (HbA1c)
  • Reagents: 32 cobas c packs, 50-800 tests per pack
  • 1,000 disposable cuvettes with 120-240 µL reaction volume
  • Low Di water consumption 2 liters per hour

cobas c pack :
Patented reagent carrier design plus on-board refrigeration prevents reagent evaporation and degradation, ensuring long-term on-board stability and long calibration
Each cobas c pack holds all necessary reagents for up to 800 determinations,
maximising on-board capacity and reducing the need for operator intervention and frequent reloading.
Reagent preparation is a task of the past.
The barcoded cobas c packs are automatically handled by the system, reducing the possibility of errors and saving staff time.
Compact design of the reagent carrier means that more than a year´s supply of tests for a typical laboratory can easily be stored in a single refrigerator.

Workflow consolidation :
More than 140 applications for all types of sample
matrices are measured with one of 4 different measuring technologies – absorbance photometry, turbidimetry,
fluorescence polarisation and ion selective

The COBAS INTEGRA 400 plus system has up to 36 different
on-board assays. For quick access to additional
tests, cobas c packs can be exchanged while the
system is running. Off-board storage of pre-calibrated
cobas c packs allows full flexibility.
The broad menu includes clinical chemistry, specific
proteins, therapeutic drug monitoring, drug of abuse
testing and much more.
Consolidation on a single system improves turnaround times by reducing the need for sample splitting.
On-board storage of 32 cobas c packs at 12°C ensures reagent stability up to 3 months, reducing reagent waste and costs.
For high volume tests, multiple cobas c packs of the same assay can be on-board for automatic switch-over during run.

Reduced costs through increased efficiency :
Consolidation eliminates pre-analytical phase tasks by reducing sample splitting to improve workflow and decrease handling costs.
Long on-board reagent stability and fewer calibrations mean less waste and lower cost per reportable result.
A single workstation optimises use of time and budget by reducing costs of operating, maintaining and servicing multiple analytical systems.
Processing time can be reduced by up to 50% compared with dedicated analysers.
Post-analytical tasks such as sample tracking, rerunning, archiving and disposal are greatly simplified by use of a single consolidated system – COBAS INTEGRA
400 plus.

Real security  :
Highly sensitive pressure sensors detect incorrect pipetting, even at 2 µL sample volume.
Handling of clotted samples is improved with immediate flagging of faulty samples.
System wash pressures have been optimised to fully remove the clot from the sample probes, avoiding any maintenance actions and interruptions to workflow

 Automatic start-up:
 Configurable start-up options ensure that the system is ready whenever needed
 Access to the full COBAS INTEGRA reagent menu 24 hours a day guarantees quick after hours turn around time
 Automatic system maintenance significantly reduces operator interventions.

Result security :
Highly sensitive pressure sensors detect incorrect pipetting, even at 2 µL sample volume.
Handling of clotted samples is improved with immediate flagging of faulty samples
System wash pressures have been optimised to fully remove the clot from the sample probe, avoiding maintenance actions and interruptions to workflow

ISE module :
Sodium, Potassium, Chloride and Lithium.

Flexible change of onboard tests
Onboard capacity of 8 racks with 4 cobas c packs each
Easy change of menu via the reagent racks
Refrigerated storage for long calibration stability.

Continuous sample loading :
6 sample racks for various primary and secondary cups
Up to 90 samples onboard, racks can be replaced after sample pipetting
Positive sample identification via barcode.

Analytical unit:
Precise temperature controlled reaction rotor ensure stable test conditions and reliable results
Sensitive photometric and turbidimetric measurements
Extremely stable LED light source for fluorescence polarisation.

Enhanced user interface :
System software is object-oriented, based on Windows XP, for standardised ease-ofuse
Intuitive online help provides instant and precise multilingual support
Easy to read 19 inch flatscreen monitor

System Specifications:

Random and continuous access, sample selective analyser
36 tests onboard
Integration of 4 measuring principles
Absorbance photometry:  Enzymes and substrates
Turbidimetry:  Specific proteins, drugs of abuse
Fluorescence polarimetry:  Therapeutic drugs, thyroid tests
Ion-selective electrode potentiometry:  Na+,K+,Cl– and Li+

Test throughput

Up to 400 tests/hr (including ISE)

Sample types:

Serum, plasma, urine, CSF, hemolysate and whole blood (HbA1c)

Sample handling:

90 primary or secondary tubes on-board
Up to 6 x RD15 racks on-board
Cooled rack position for controls and calibrators
Automatic sample dilution and concentration
Barcode reading via laser scanner, with immediate STAT recognition

Sample container types :

Primary tubes: 5 to 10 mL; 16x100, 16x75, 13x100, 13x75 mm with closed cap for  Hitachi microcup, 500 µL; Hitachi standard cup, 1.5 mL;
cobas cup, 650 µL; Eppendorf cup, 1.5 mL; Cup on tube definable

Sample volume :

Typically 2 to 10 µL per test, ISE indirect 20 µL, ISE direct 97 µL

Sample barcode types:

Code 128, Codabar, Code 2 of 5 interleaved, Code 39.

Reagents onboard capacity:

32 cobas c packs, 50-800 tests per cobas c pack
Up to 8 racks of 4 cobas c packs on-board
Reagent compartment cooled to 10-15°C
Onboard stability up to 3 months, calibration typically each lot.

Reaction cells:

Holds 1,000 disposable cuvettes with 5 mm path length,
and 120-240 µL reaction volume.

System interfaces :

RS 232 serial interface, bi-directional, inbuilt modem for remote diagnostics access.

Electrical requirements:

100-125/200-240 Volts AC, 50 or 60 Hz,
Power consumption 1,200 VA

Physical dimensions:

Width: 135 cm (53.1 in)
Depth: 66 cm (25.9 in)
Height: 75 cm (28.5 in)


320 kg (506 lbs)

Water requirements :

Up to 2 liters per hour in operating mode, Type 1 NCCLS.

Certification :




Technical Spec Value

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